Highly pure and concentrated Growth Factor Serum (EGF) and STABLE Vitamins are the most effective anti-ageing ingredients available on the market, they work synergistically to provide long lasting and visible results.


To effectively fight against skin ageing, Medik8 has a simple solution:


- Vitamin C in the morning
EGF in the morning and in the evening
Vitamin A in the evening


Combining Vitamins and EGF will yield quicker and better results that last much longer. Together, EGF and Vitamins A and C stimulate and enhance nearly all major components of the skin (dermis and epidermis), either complementing each other or fulfilling in areas where the other does not have much of an effect.


Our natural skin regeneration process is controlled by many molecules and messengers, not just one molecule!
The combination of Vitamin A, Vitamin C and EGF brings us closer still to replicating the body’s natural function.

 

Q. Is there a connection between Vitamin A and Epidermal Growth Factor (EGF)?


A. Yes, you could say this.


Vitamin A and EGF both increase cellular proliferation and differentiation, however, their mechanism of action is slightly different from one another.


Skin cells have tiny receptors on their surface which can be activated by biological and non-biological molecules. There are specialised receptors for EGF and there are also specialised receptors for vitamin A.


At some point down the biochemical pathway there will be some overlap in their mechanism of action, because the signals eventually reach the “mastermind” of the cell which we all know as DNA. With the presence of EGF, the cells are in an active state and the regeneration process is speeded up. i.e.they are fuelled and ready to respond to other stimuli.


At this point their response to Vitamin A will be stronger and better.

 

Q. Vitamin A has many benefits – slowing sebum production, refining pores, collagen & elastin production, normalizing melanocyte function etc are there any other benefits to EGF?


A. Yes.


EGF has an important effect on the epidermis. EGF has been proven to increase epidermal differentiation, to improve epidermal cells viability and to increase the number of cellular layers: resulting in a thicker epidermis. (see Medik8 Study Report: Assessment of anti-ageing activity of growth factor on the epidermal and dermal structures of human ex vivo skin explants).


EGF also increases neovascularisation. This basically means that there are more tiny blood vessels supplying skin cells with essential nutrients and food. Combined with their ability to directly stimulate cells just like they are stimulated naturally, results can be more profound and longer lasting.


EGF also has a regulatory effect on enzymes responsible for breaking down components of the dermis. They ensure that the newly produced collagen is laid down in the right order and does not simply accumulate over the existing old collagen. With the presence of EGF new collagen replaces old collagen, fixing the foundation rather than patching it up.


EGF helps melanin dispersion which means pigments are evenly spread out because of the increased cellular turnover of epidermal cells (keratinocytes).

 

Q. Why would client prefer EGF to Vitamin A?


A. Usually compliance (tolerance to Vitamin A).


Vitamin A is highly recommended by any professional skincare expert and should be the cornerstone of any skincare routine.
For some clients, however, the main concern associated with using Vitamin A is the skin sensitivity that may result from its use, especially when exposed to sunlight. Applying Vitamin A to the skin may also sting. This is why Medik8’s time-release (and therefore non-stinging) Retinol (Vitamin A) products are so popular and also why Medik8 recommend application of Vitamin A at night.


In rare cases, Vitamin A sensitivity can cause redness, dryness and flaking of the skin. If such problems are experienced by the client, EGF is the perfect substitute. Medik8’s Youth Activating Growth Factor formula is very gentle and virtually non-irritating to all skin types.


Due to genetic variations, the number and/or activity of cellular receptors that respond to EGF and Vitamin A differ from person to person. This will have a direct impact on treatment response and the quality of result achieved. It is perfectly normal for individuals to respond differently to EGF or Vitamin A. In such cases a client may choose EGF over Vitamin A or vice versa.


There are also different benefits of each as outlined in the previous and subsequent questions.

 

Q. Why should client use both?


A. Synergy. i.e. overall better results.


It is important to remember that the pathological processes responsible for skin aging are very complex and multifactorial in nature. As a result, a strategic combination of treatments must be adopted to address all the changes in the skin, in order to achieve optimum results.


The extracellular matrix (ECM) is made up of several components with collagen being the most abundant. Both EGF and Vitamin A increase collagen production in the dermis, however, only vitamin A can significantly boost elastin and fibrillin production at cellular levels (DNA) which are essential for the formation of healthy extra cellular matrix.


Elastin fibers are the ‘rubberband’ fibres responsible for the ‘snap back’ quality of young skin, while collagen network contributes to strength, structure, firmness and overall appearance of skin.


EGF are more effective at stimulating epidermal cell proliferation and prolonging cellular survival which can lead to longer lasting results. The increase in epidermal thickness can instantly reduce minor imperfections in the skin. Besides promoting proliferation and differentiation, they can also enhance cellular survival.

 

Q. What is the benefit of adding Vitamin C to the skincare routine?


Scientific Facts about Vitamin C:
•It is an essential coenzyme for the synthesis of collagen
•It is essential for the transportation of collagen molecules into the dermis
•It is an excellent free radical scavenger (antioxidant)
•It disrupts melanin synthesis in melanocytes, reducing pigmentation


Furthermore without sufficient levels of vitamin C, collagen formation is disrupted and the collagen molecules formed are structurally weak and therefore rapidly degraded.


When fibroblasts are stimulated to increase collagen synthesis (by Vitamin A and/or EGF) , naturally a higher demand for vitamin C is created. The body cannot store vitamin C efficiently, hence why a daily consumption is highly recommended.


As a result, a rich supply of vitamin C is essential for the formation of healthy collagen in dermis.
Previous studies have successfully demonstrated that extended exposure of human connective tissue cells to vitamin C can stimulate collagen synthesis by an eight-fold increase in production.

 

Medik8 highly recommend a combination treatment approach for optimal results


Combining Vitamins and EGF will yield quicker and better results that last much longer. Together, EGF and Vitamins A and C stimulate and enhance nearly all major components of the skin (dermis and epidermis), either complementing each other or fulfilling in areas where the other does not have much of an effect.Our natural skin regeneration process is controlled by many molecules and messengers, not just one molecules.


The combination of Vitamin A, Vitamin C and EGF brings us closer still to replicating the body’s natural function.